On April 11, research results were published about testing on the (formerly) interesting idea that non-steroidal anti-inflammatory drugs (NSIDs) could prevent or treat AD. The idea was intriguing, and some epidemiological studies had suggested that it might work. Recall that inflammation plays a significant role in the disease process for AD and may be part of the way in which it begins. Therefore, it seemed reducing inflammation would combat the disease.
Does it work? No, and it may make things slightly worse.
What are NSIDs? These are (often) over-the-counter pain relievers, like aspirin, ibuprofen, and naproxen. (Tylenol can reduce inflammation, but it is not an NSID.) NSIDs relieve pain by reducing inflammation.
This week's issue of ALZForum featured an article, "Closing the Book on NSAIDs for Alzheimer’s Prevention." It reported on the early termination of the INTREPAD trial. Preliminary results showed no benefit with respect to AD, but downsides such as causing and aggravating cardiovascular problems.
As we discussed in a post on March 2, 2109, sound diet and exercise are your best weapons against inflammation.
In Beating the Dementia Monster, we commented on reports that anti-inflammatory medications might treat AD. We'll need to make sure that's not in the second edition!
In my book, "Beating the Dementia Monster," I describe what has occurred since 2015 when I first knew I had memory problems. (You can find it on Amazon.com.) I have experienced remarkable improvement, and I’m certain that I can share valuable information with many others. In this second edition I continue my story to 2020 and provide greater understanding of how Alzheimer's advances and why what I did worked.
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