Insulin Study Results Are Not Promising

I got a call today from a research coordinator at the VA hospital in Seattle, where we had participated in the SNIFF study.  He said that the research results were beginning to come out, and they had not identified a significant difference in cognitive test results between subjects who were on actual insulin and those who were on the placebo.  The SNIFF study evaluated the effect of insulin provided directly to the brain without raising insulin levels in other parts of the body.  Since AD affects the metabolism of glucose in the brain, it was hoped that boosting insulin concentration in the brain at key times would improve uptake and utilization of glucose by the cells, thereby improving cognition. 

Here is a discussion in the ALZ Forum that I missed regarding how things went on the SNIFF study.  It's from November of last year.

You will recall that I was on the placebo during the one-year placebo-controlled phase of the study.  During the subsequent six months, all of us were on the real insulin.  The research coordinator said the results of the latter phase have not yet been released.  I doubt they will change the conclusions as they are now emerging.