Tuesday, April 23, 2024

A free, online test for cognitive impairment

A friend told me that he had taken some online tests for depression and cognitive impairment.  He is almost as old as I am and was curious about what the tests would find.  They found that he was not depressed, and he was not cognitively impaired.  Had they asked me, I'd have told them the same.  The test uses AI to analyze your discussion of a picture to find markers for cognitive impairment.  I know there has been a lot of research in this area.  In fact, I've participated in some.

The idea was intriguing, so I thought I'd give it a try too.  It's provided by a company called LANGaware, and no referral or medical review is required.  They claim, "LANGaware is a clinically validated cognitive health screening tool powered by AI and patented machine learning.  Analyzing language and speech patterns, LANGaware offers insights into your brain health, delivering probability results for cognitive health conditions."

You take the short test, the AI robot interprets it, and you get the results in a few minutes.  If you're disturbed by the results, it's up to you to take it to your medical provider.  What could be easier?

I am tested by researchers at the University of Washington's Harborview Medical Center every week, and I feel well about how I do on those tests.  So I wondered what this AI robot would find.  

Well, it said I am in the middle of the cognitively impaired range.

In taking the test, the first thing I did was inadvertently take a test on depression.  Not surprisingly, it found that I'm not depressed, but ... was part of the test to see if I could follow instructions to get to the right test?

The cognitive test was actually familiar to me, although I never knew how I was evaluated.  Since 2015, I've had comprehensive cognitive testing every year or two, although we are currently skipping two years before my next test.  In this test, I was shown a picture and was told to explain verbally what I saw going on in the picture.  The picture was familiar, and I could recall what I'd seen in the same picture different times over the years.

So I was surprised when I found that I hadn't done well.  There was a discussion of eight different parameters, and I figured I was evaluated using them.  When I read about each one, I concluded that I hadn't spoken formally enough, not using complete sentences with good grammar, etc., and that's why I had scored poorly.  You're allowed to take the tests as often as you like, so I took it again.  This time I was careful to use my very best diction and grammar.  (In Beating the Dementia Monster, we discuss how the practice effect can confound cognitive testing.)

The second time, I scored in the normal (not impaired) range, but I noticed that the results evaluation showed me different parameters used for evaluation.  I'm guessing I was actually evaluated on even more parameters, but, for some reason, these were the most interesting for this taking of the test.  So while my overall score put me in the "normal" range for cognition, I was graded down on "lexical variation," "reference pointers," and "duration of speech."  Only "reference pointers" was mentioned in the first test.  When I was graded down, a score was marked as, "a participant with significant cognitive decline."  Ouch.

On the other hand, the second AI robot may have taken a different approach to evaluating me.  This might be why it got a different result.  But I don't know.

Here's a graphical representation of my first test:

If you can see it, the largest colored area is healthy people.  The purple triangle in the middle represents some cohort of patients with cognitive impairment.  I'm the green; more OK than the patients with cognitive impairment, but a long way from the healthy cohort.

I'm thinking I'll take the test again tomorrow.  No telling what I'll find.

Tuesday, April 16, 2024

Early exposure to a "western diet" impairs memory function. Uh oh.

Yes, it's been more than two weeks since I last posted. I've had plenty to keep me busy; I'm not just running out of gas.  I hear from some of you who worry about me.  But I'm OK.

I came across some recent research with implications for the diets of children and later memory loss.  But there's no real news.  Saturated fats, refined sugar, refined flour, and otherwise processed foods are still bad.  Very bad.  What's new in this research is that the negative effects begin with children when they are on what they referred to as a "western diet."  You know, pizza, red meat, fast food, and other processed foods.  (According to the late Dr. Martha Clare Morris, in her book Diet for the Mind, pizza seems to be the very worst thing for your brain that you can take in...)

The research was published in the journal Brain, Behavior, and Immunity.  The article was "Western diet consumption impairs memory function via dysregulated hippocampus acetylcholine signaling."  The researchers claimed to find causes and effects in several areas we've discussed before, both in Beating the Dementia Monster and in this blog.  For example, the western diet is hard on the gut microbiome that has such an important regulatory function for the brain.  Also, the western diet disrupts processes in the hippocampus that are so vital to memory.

Now, to be fair to McDonald's, the research was conducted with rats, not people.  And we've discussed before how brain research results from rodent models applied to people has sometimes been discredited.  In this case, the researchers wanted to know what would happen if rats ate a western diet during their juvenile stage of development, 26 to 56 days after their birth.  The rats were fed cafeteria-style, giving them the opportunity to choose whatever (junk) food they wanted.

I'm thinking this age may correspond, in people years, to when I began to earn enough money to begin eating fast food on my own.  Fast food became my regular diet at a fairly young age.  So maybe diet in my juvenile years has something to do with why I'm where I'm at today.  But I'm confident that generally following the MIND diet over the past seven or eight years has contributed to my present well-being.

Still Me; Accepting Alzheimer's Without Losing Yourself, by Rebecca S. Chopp, PhD

Back in October, I wrote about Dr. Rebecca Chopp who was writing a book on her experience with an Alzheimer's diagnosis .  I had stumbl...